{"id":11,"date":"2022-05-11T17:41:07","date_gmt":"2022-05-11T17:41:07","guid":{"rendered":"http:\/\/radweb.su.domains\/cirp\/?page_id=11"},"modified":"2023-04-20T16:36:29","modified_gmt":"2023-04-20T16:36:29","slug":"about","status":"publish","type":"page","link":"https:\/\/radweb.su.domains\/cirp\/about\/","title":{"rendered":"About"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"11\" class=\"elementor elementor-11\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-8072168 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"8072168\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-1160776\" data-id=\"1160776\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e66b9c8 elementor-widget elementor-widget-heading\" data-id=\"e66b9c8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-xl\">About Stanford CIRP<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-81a8e7d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"81a8e7d\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-1b998e0\" data-id=\"1b998e0\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f0e330d elementor-tabs-view-horizontal elementor-widget elementor-widget-tabs\" data-id=\"f0e330d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"tabs.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-tabs\">\n\t\t\t<div class=\"elementor-tabs-wrapper\" role=\"tablist\" >\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-tab-title-2521\" class=\"elementor-tab-title elementor-tab-desktop-title\" aria-selected=\"true\" data-tab=\"1\" role=\"tab\" tabindex=\"0\" aria-controls=\"elementor-tab-content-2521\" aria-expanded=\"false\">Project Aims<\/div>\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-tab-title-2522\" class=\"elementor-tab-title elementor-tab-desktop-title\" aria-selected=\"false\" data-tab=\"2\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-2522\" aria-expanded=\"false\">Aim 1<\/div>\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-tab-title-2523\" class=\"elementor-tab-title elementor-tab-desktop-title\" aria-selected=\"false\" data-tab=\"3\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-2523\" aria-expanded=\"false\">Aim 2<\/div>\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-tab-title-2524\" class=\"elementor-tab-title elementor-tab-desktop-title\" aria-selected=\"false\" data-tab=\"4\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-2524\" aria-expanded=\"false\">Aim 3<\/div>\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-tab-title-2525\" class=\"elementor-tab-title elementor-tab-desktop-title\" aria-selected=\"false\" data-tab=\"5\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-2525\" aria-expanded=\"false\">Long-term Impact<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t<div class=\"elementor-tabs-content-wrapper\" role=\"tablist\" aria-orientation=\"vertical\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-tab-title elementor-tab-mobile-title\" aria-selected=\"true\" data-tab=\"1\" role=\"tab\" tabindex=\"0\" aria-controls=\"elementor-tab-content-2521\" aria-expanded=\"false\">Project Aims<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-2521\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-2521\" tabindex=\"0\" hidden=\"false\">Advances in diagnosis, surgery and chemotherapy have improved clinical outcomes for patients with localized bone sarcomas<sup>1-3<\/sup>. However, the overall survival of patients with metastatic disease continues to be less than 30%<sup>4-10<\/sup>. Thus, there is an urgent need for new therapies which can improve outcomes in these patients<sup>3,9,10<\/sup>. Recent studies have shown that the transmembrane protein CD47 is a critical regulator of osteosarcoma growth and metastasis<sup>11<\/sup>. Therefore, inhibition of CD47 represents a new and promising therapeutic approach.\u00a0CD47 expression on sarcoma cells functions as a \u201cdon\u2019t eat me\u201d signal by engaging signal-regulatory protein alpha (SIRP\u03b1), an inhibitory receptor on tumor associated macrophages (TAM)<sup>12,13<\/sup>. CD47 monoclonal antibodies (mAbs) block the interaction between CD47 and SIRP\u03b1, and thereby, activate TAM to phagocytose cancer cells<sup>14-18<\/sup>.\u00a0Recent work in animal models of sarcomas showed that CD47 mAb therapy significantly reduced tumor growth and increased survival <sup>19-21<\/sup>. However, tailoring CD47 mAb therapy for pediatric patients is difficult due to a lack of clinically established biomarkers, which can monitor TAM response in vivo. Since immunotherapy does not lead to a decrease in tumor size, at least not in the immediate post-treatment phase, we urgently need new quantitative imaging (QI) tools that can monitor tumor response to these novel therapies <b>The overall goal of our project is to optimize and validate preclinical and clinical quantitative imaging techniques for <i>in vivo<\/i> quantification of tumor associated macrophages (TAM) in osteosarcomas.<\/b> We are in a unique position to leverage an immediately clinically applicable TAM imaging test, which was developed in our lab, to study the efficacy of TAM-modulating therapies. Our approach relies on the FDA approved iron oxide nanoparticle compound ferumoxytol, which is phagocytosed by TAM and can be detected with magnetic resonance imaging (MRI). Our preliminary data provide proof-of-concept that ferumoxytol-MRI can detect TAM in osteosarcomas in mouse models<sup>21<\/sup> and patients <sup>22<\/sup>. We also showed that ferumoxytol-MRI can monitor tumor response to immune-modulating therapies in mouse models <sup>23<\/sup>. To develop <b>quantitative imaging (QI) methods for monitoring cancer therapy response<\/b> to TAM activating cancer immunotherapy, we propose the following specific aims:<\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-tab-title elementor-tab-mobile-title\" aria-selected=\"false\" data-tab=\"2\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-2522\" aria-expanded=\"false\">Aim 1<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-2522\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-2522\" tabindex=\"0\" hidden=\"hidden\"><h3>Optimize and validate pre-clinical quantitative imaging methods for TAM imaging\u00a0<\/h3><p>Our preliminary data showed a specific cellular uptake of ferumoxytol in TAM in osteosarcomas in mouse models and corresponding significant tumor enhancement on T2- and T2*-weighted MR images at 24 hours after intravenous nanoparticle injection<sup>21<\/sup>. With this aim, we will define the appropriate time window for TAM imaging, determine the reproducibility of quantitative TAM imaging results and identify potentially confounding signal effects. All imaging studies will be performed on a 3T MRI scanner, which resembles the typical clinical situation. The endpoint will be to validate a quantitative TAM imaging test in an established animal model.<\/p><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-tab-title elementor-tab-mobile-title\" aria-selected=\"false\" data-tab=\"3\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-2523\" aria-expanded=\"false\">Aim 2<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-2523\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"3\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-2523\" tabindex=\"0\" hidden=\"hidden\"><h3>Implement the optimized methods in a co-clinical trial\u00a0<\/h3><p>We recently conducted a first-in-human clinical trial, which showed that ferumoxytol nanoparticles cause strong MRI enhancement of bone sarcomas. A hypointense (dark) tumor enhancement on T2-weighted MRI images correlated with the presence and distribution of TAM on histology<sup>22<\/sup>. However, it is not known whether this new imaging test can be used to predict response to TAM-modulating therapies. We hypothesize that the degree of ferumoxytol tumor MRI enhancement after TAM-modulating therapy correlates with the quantity of TAM and the extent of tumor necrosis on histology. The endpoint will be to prove that quantitative ferumoxytol-enhanced MRI can serve as a surrogate outcome measure for tumor response to TAM modulating therapies.\u00a0<\/p><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-tab-title elementor-tab-mobile-title\" aria-selected=\"false\" data-tab=\"4\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-2524\" aria-expanded=\"false\">Aim 3<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-2524\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"4\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-2524\" tabindex=\"0\" hidden=\"hidden\"><h3>Populate a web-accessible research resource\u00a0<\/h3><p><span style=\"font-weight: 400;\">Finally, we will populate a web-accessible research resource with all the methods, data and results collected from the co-clinical investigations such that investigators at other centers can learn about quantitative imaging approaches for TAM imaging, test their ability to estimate tumor TAM content through R2 and R2* maps, implement related imaging protocols at their institution and apply them for monitoring TAM-modulating cancer immunotherapies. We will invite the research community to participate in a software challenge that could further optimize the speed and accuracy of QI methods for TAM quantification.<\/span><\/p><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-tab-title elementor-tab-mobile-title\" aria-selected=\"false\" data-tab=\"5\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-2525\" aria-expanded=\"false\">Long-term Impact<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-2525\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"5\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-2525\" tabindex=\"0\" hidden=\"hidden\"><p><span style=\"font-weight: 400;\">Optimal integration of TAM-modulating therapies with conventional chemotherapy remains poorly elucidated, despite the fact that clinical implementation will rely on combinations. Ferumoxytol-MRI could represent a <\/span><b>significant breakthrough<\/b> <span style=\"font-weight: 400;\">for clinicians as a new means for therapy stratification and gold-standard imaging test for monitoring response to TAM-modulating therapies. Results from this project will directly inform ongoing clinical trials, including a<\/span><b> first-in-patient CD47 mAb trial in 2021<\/b><span style=\"font-weight: 400;\">. <\/span><b>Our investigations will be readily translated to the clinic, provide a novel tool to predict tumor response to new immunotherapies, have major and broad health care impact, and ultimately, help to improve long-term outcomes<\/b><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p><\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5b49957 elementor-section-stretched elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5b49957\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;,&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-10ccbcc\" data-id=\"10ccbcc\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2c49d9c elementor-widget elementor-widget-heading\" data-id=\"2c49d9c\" data-element_type=\"widget\" data-e-type=\"widget\" id=\"team\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-large\">The Team<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5f69bb8 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5f69bb8\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-dbff393\" data-id=\"dbff393\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9b0abd0 elementor-widget elementor-widget-image\" data-id=\"9b0abd0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"249\" height=\"300\" src=\"https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2022\/05\/Screen-Shot-2022-05-13-at-2.09.20-PM-249x300.png\" class=\"attachment-medium size-medium wp-image-76\" alt=\"Heike Daldrup-Link\" srcset=\"https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2022\/05\/Screen-Shot-2022-05-13-at-2.09.20-PM-249x300.png 249w, https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2022\/05\/Screen-Shot-2022-05-13-at-2.09.20-PM.png 592w\" sizes=\"(max-width: 249px) 100vw, 249px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6ce458c elementor-widget elementor-widget-heading\" data-id=\"6ce458c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Heike Daldrup-Link, MD, PhD<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1a67d28 elementor-widget elementor-widget-text-editor\" data-id=\"1a67d28\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Co-Principal Investigator<\/strong><br \/>Professor of Radiology at Stanford University<br \/>Co-Director of the Cancer Imaging Program at the Stanford Cancer Institute\u00a0<\/p><p><span style=\"font-weight: 400;\">Dr. Daldrup-Link has over fifteen years of experience in clinical cancer imaging, MR imaging and nanoparticle research. Dr. Daldrup-Link is the recipient of multiple honors and awards for translational research, including the Distinguished Investigator Award of the Academy for Radiology Research, member of the American Society for Clinical Investigation (ASCI, honor society for physician-scientists) and Fellow of the American Institute for Medical and Biomedical Engineering (AIMBE). <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-20c6859\" data-id=\"20c6859\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3e42282 elementor-widget elementor-widget-image\" data-id=\"3e42282\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"237\" height=\"300\" src=\"https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2022\/05\/Screen-Shot-2022-05-13-at-2.09.28-PM-e1652555879443-237x300.png\" class=\"attachment-medium size-medium wp-image-77\" alt=\"Daniel Rubin\" srcset=\"https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2022\/05\/Screen-Shot-2022-05-13-at-2.09.28-PM-e1652555879443-237x300.png 237w, https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2022\/05\/Screen-Shot-2022-05-13-at-2.09.28-PM-e1652555879443.png 467w\" sizes=\"(max-width: 237px) 100vw, 237px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0f99342 elementor-widget elementor-widget-heading\" data-id=\"0f99342\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Daniel Rubin, MD<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-42dd6ee elementor-widget elementor-widget-text-editor\" data-id=\"42dd6ee\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Co-Principal Investigator<\/strong><br \/>Professor of Radiology,\u00a0Biomedical Data Science, and Medicine (Biomedical Informatics Research) at Stanford University<\/p><p><span style=\"font-weight: 400;\">Dr. Rubin is an expert in quantitative image analysis methods in Radiology. He is a Fellow of the American Institute for Medical and Biological Engineering (AIMBE), Fellow of the American College of Medical Informatics (ACMI) and Fellow of the Society of Imaging Informatics in Medicine (SIIM).\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-229e5f1\" data-id=\"229e5f1\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-00b00b0 elementor-widget elementor-widget-image\" data-id=\"00b00b0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"240\" height=\"300\" src=\"https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2022\/05\/Screen-Shot-2022-05-13-at-2.09.33-PM-240x300.png\" class=\"attachment-medium size-medium wp-image-78\" alt=\"Michael Moseley\" srcset=\"https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2022\/05\/Screen-Shot-2022-05-13-at-2.09.33-PM-240x300.png 240w, https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2022\/05\/Screen-Shot-2022-05-13-at-2.09.33-PM.png 468w\" sizes=\"(max-width: 240px) 100vw, 240px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0329b64 elementor-widget elementor-widget-heading\" data-id=\"0329b64\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Michael Moseley, PhD<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e22ae7c elementor-widget elementor-widget-text-editor\" data-id=\"e22ae7c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Co-Investigator<\/strong><br \/>Professor of Radiology at Stanford University<\/p><p><span style=\"font-weight: 400;\">Dr. Moseley has <\/span><span style=\"font-weight: 400;\">a PhD in physical chemistry and expertise in novel high-speed MR imaging techniques for cellular imaging. Dr. Moseley published over 380 publications on MR imaging, he was awarded the ISMRM (International Society for Magnetic Resonance and Medicine) Gold Medal in 2001 for his pioneering work in diffusion MRI and he served as the 2003-2004 president of the ISMRM.\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-9e9363a elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"9e9363a\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-e949765\" data-id=\"e949765\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-267e08a elementor-widget elementor-widget-image\" data-id=\"267e08a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"270\" height=\"300\" src=\"https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2022\/05\/Screen-Shot-2022-05-13-at-2.09.39-PM-270x300.png\" class=\"attachment-medium size-medium wp-image-79\" alt=\"Sheri Spunt\" srcset=\"https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2022\/05\/Screen-Shot-2022-05-13-at-2.09.39-PM-270x300.png 270w, https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2022\/05\/Screen-Shot-2022-05-13-at-2.09.39-PM.png 532w\" sizes=\"(max-width: 270px) 100vw, 270px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-199ce5a elementor-widget elementor-widget-heading\" data-id=\"199ce5a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Sheri Spunt, MD, MBA<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-19880a4 elementor-widget elementor-widget-text-editor\" data-id=\"19880a4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Co-Investigator<\/strong><br \/>Professor of Pediatrics at Stanford University<\/p><p><span style=\"font-weight: 400;\">Dr. Spunt is a pediatric oncologist with Board Certification in Pediatrics and subspecialty certification in Pediatric Oncology. Dr. Spunt directs a Clinical and Translational Research Program focusing on the development of novel therapy approaches for bone and soft tissue sarcomas in children and young adults.\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-d8aad1b\" data-id=\"d8aad1b\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5817713 elementor-widget elementor-widget-image\" data-id=\"5817713\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"240\" height=\"300\" src=\"https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2022\/05\/Screen-Shot-2022-05-13-at-2.09.48-PM-240x300.png\" class=\"attachment-medium size-medium wp-image-80\" alt=\"\" srcset=\"https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2022\/05\/Screen-Shot-2022-05-13-at-2.09.48-PM-240x300.png 240w, https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2022\/05\/Screen-Shot-2022-05-13-at-2.09.48-PM.png 462w\" sizes=\"(max-width: 240px) 100vw, 240px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-900f082 elementor-widget elementor-widget-heading\" data-id=\"900f082\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Robbie Majzner, MD<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f6f5d07 elementor-widget elementor-widget-text-editor\" data-id=\"f6f5d07\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Co-Investigator<\/strong><br \/>Assistant Professor of Pediatrics,<br \/>Pediatric Oncology Division, at Stanford University<\/p><p><span style=\"font-weight: 400;\">Dr. Majzner completed his residency training in pediatrics at New York Presbyterian-Columbia and fellowship training in pediatric hematology-oncology at Johns Hopkins and the National Cancer Institute. His current work focuses on investigating the value of combined GD2 and CD47 mAb therapies for the treatment of neuroblastomas and osteosarcomas.\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-b7e5b3a\" data-id=\"b7e5b3a\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7dda7e7 elementor-widget elementor-widget-image\" data-id=\"7dda7e7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"217\" height=\"300\" src=\"https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2022\/05\/Screen-Shot-2022-05-13-at-2.09.58-PM-217x300.png\" class=\"attachment-medium size-medium wp-image-81\" alt=\"Frezghi Habte\" srcset=\"https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2022\/05\/Screen-Shot-2022-05-13-at-2.09.58-PM-217x300.png 217w, https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2022\/05\/Screen-Shot-2022-05-13-at-2.09.58-PM.png 496w\" sizes=\"(max-width: 217px) 100vw, 217px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ffd5346 elementor-widget elementor-widget-heading\" data-id=\"ffd5346\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Frezghi Habte, PhD<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ce23869 elementor-widget elementor-widget-text-editor\" data-id=\"ce23869\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Director<br \/><\/strong>Stanford Center for Innovation in In Vivo Imaging (SCI<sup>3<\/sup>)<\/p><p><span style=\"font-weight: 400;\">Dr. Habte is a medical imaging instrumentation and image quantification specialist. As a director of the shared small animal imaging facility at Stanford, he provides various services such as instrument management and support, project specific experimental design consultation, and image analysis software support and training. His current research focuses on image data management and quantitative imaging methods.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7608954 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"7608954\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-a34f2c5\" data-id=\"a34f2c5\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3517cdc elementor-widget elementor-widget-image\" data-id=\"3517cdc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"217\" height=\"300\" src=\"https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2022\/05\/Screen-Shot-2022-05-13-at-2.10.03-PM-217x300.png\" class=\"attachment-medium size-medium wp-image-82\" alt=\"Raheleh Roudi\" srcset=\"https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2022\/05\/Screen-Shot-2022-05-13-at-2.10.03-PM-217x300.png 217w, https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2022\/05\/Screen-Shot-2022-05-13-at-2.10.03-PM.png 398w\" sizes=\"(max-width: 217px) 100vw, 217px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-960fba0 elementor-widget elementor-widget-heading\" data-id=\"960fba0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Raheleh Roudi, PhD<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-741d45a elementor-widget elementor-widget-text-editor\" data-id=\"741d45a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Postdoctoral Research Fellow at Stanford University<\/p><p><span style=\"font-weight: 400;\">Dr. Roudi is a molecular biologist who has worked as a researcher in the Department of Radiology for 2 years. She conducts our pre-clinical imaging studies with a focus on MR imaging and R2\/R2* measurements.\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-03a93bc\" data-id=\"03a93bc\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b9fd599 elementor-widget elementor-widget-image\" data-id=\"b9fd599\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"217\" height=\"300\" src=\"https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2022\/05\/Screen-Shot-2022-05-13-at-2.10.10-PM-217x300.png\" class=\"attachment-medium size-medium wp-image-83\" alt=\"Shakthi Kuraran Ramasamy\" srcset=\"https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2022\/05\/Screen-Shot-2022-05-13-at-2.10.10-PM-217x300.png 217w, https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2022\/05\/Screen-Shot-2022-05-13-at-2.10.10-PM.png 468w\" sizes=\"(max-width: 217px) 100vw, 217px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-57b0abd elementor-widget elementor-widget-heading\" data-id=\"57b0abd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Shakthi Kuraran Ramasamy, MD<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-32ce05b elementor-widget elementor-widget-text-editor\" data-id=\"32ce05b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Postdoctoral Research Fellow at Stanford University<\/p><p><span style=\"font-weight: 400;\">Dr. Ramasamy is a physician-scientist who has worked as a researcher in the Department of Radiology for 2 years. He coordinates and supervises our imaging studies with a focus on MR imaging and R2\/R2* measurements.\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-56903c6\" data-id=\"56903c6\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e2a7950 elementor-widget elementor-widget-image\" data-id=\"e2a7950\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"257\" height=\"300\" src=\"https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2022\/05\/Screen-Shot-2022-05-13-at-2.10.18-PM-257x300.png\" class=\"attachment-medium size-medium wp-image-84\" alt=\"Lucia Barrato\" srcset=\"https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2022\/05\/Screen-Shot-2022-05-13-at-2.10.18-PM-257x300.png 257w, https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2022\/05\/Screen-Shot-2022-05-13-at-2.10.18-PM.png 382w\" sizes=\"(max-width: 257px) 100vw, 257px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-40236de elementor-widget elementor-widget-heading\" data-id=\"40236de\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Lucia Baratto, MD<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-736ae9a elementor-widget elementor-widget-text-editor\" data-id=\"736ae9a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Research Associate<\/p><p><span style=\"font-weight: 400;\">Dr. Barratto is a physician-scientist who has worked as a researcher in the Department of Radiology for 5 years. Dr. Barratto acquired extensive experience in the conduction of clinical trials for the evaluation of new imaging technologies. She coordinates and supervises our imaging studies with a focus on PET imaging.\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-623d97c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"623d97c\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-d75cbf3\" data-id=\"d75cbf3\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8d9dec7 elementor-widget elementor-widget-image\" data-id=\"8d9dec7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"225\" height=\"300\" src=\"https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2023\/04\/Pisani_Fabrizio-225x300.jpg\" class=\"attachment-medium size-medium wp-image-190\" alt=\"Pisani_Fabrizio\" srcset=\"https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2023\/04\/Pisani_Fabrizio-e1682007760831.jpg 225w, https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2023\/04\/Pisani_Fabrizio-768x1024.jpg 768w, https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2023\/04\/Pisani_Fabrizio-1152x1536.jpg 1152w\" sizes=\"(max-width: 225px) 100vw, 225px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d4ed0f1 elementor-widget elementor-widget-heading\" data-id=\"d4ed0f1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Fabrizio Pisani, MD<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ce5af92 elementor-widget elementor-widget-text-editor\" data-id=\"ce5af92\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Research Associate<\/p><p>Dr. Pisani is a physician-scientist who recently joined the Molecular Imaging Program in the Department of Radiology. He coordinates and analyzes our MR imaging studies of osteosarcomas in animal models and in patients.\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-3e78b88\" data-id=\"3e78b88\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-50a33f6 elementor-widget elementor-widget-image\" data-id=\"50a33f6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"240\" height=\"300\" src=\"https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2023\/04\/pisani4x5b-240x300.jpg\" class=\"attachment-medium size-medium wp-image-193\" alt=\"\" srcset=\"https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2023\/04\/pisani4x5b-e1682007927748.jpg 240w, https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2023\/04\/pisani4x5b-819x1024.jpg 819w, https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2023\/04\/pisani4x5b-768x960.jpg 768w\" sizes=\"(max-width: 240px) 100vw, 240px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-98f9fbe elementor-widget elementor-widget-heading\" data-id=\"98f9fbe\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Laura Pisani, PhD<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c73e641 elementor-widget elementor-widget-text-editor\" data-id=\"c73e641\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Research Associate<\/p><p>Dr. Pisani is an MRI physicist and Co-Director of the Stanford Center for Innovation in <em>in vivo <\/em>Imaging (SCI3). She trains researchers in MR imaging technologies and supervises preclinical MR imaging studies at the SAIF.\u00a0Dr. Pisani provides monthly Introductory MRI seminars; hands-on training for MRI, micro-PET, fluorescence imaging; and she helps optimize experimental design and image data analysis.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-d3d243a\" data-id=\"d3d243a\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c12d6a5 elementor-widget elementor-widget-image\" data-id=\"c12d6a5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"262\" height=\"300\" src=\"https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2022\/05\/favico-262x300.png\" class=\"attachment-medium size-medium wp-image-13\" alt=\"\" srcset=\"https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2022\/05\/favico-262x300.png 262w, https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2022\/05\/favico-895x1024.png 895w, https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2022\/05\/favico-768x878.png 768w, https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2022\/05\/favico.png 960w\" sizes=\"(max-width: 262px) 100vw, 262px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0d58443 elementor-widget elementor-widget-heading\" data-id=\"0d58443\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Jarrett Rosenberg, PhD<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a1393ad elementor-widget elementor-widget-text-editor\" data-id=\"a1393ad\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Biostatistician at Stanford University<\/p><p><span style=\"font-weight: 400;\">Dr. Rosenberg is the biostatistician for the Department of Radiology and has been involved with the experimental design of this project, with respect to sample size determination, development of multiple regression analyses and correlation models for imaging data analyses. Dr. Rosenberg will work with the PIs to develop a statistical model that relates features of our integrated database to determine quantitative imaging predictors of treatment response.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6d01e88 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6d01e88\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-d59a40d\" data-id=\"d59a40d\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0eb6044 elementor-widget elementor-widget-image\" data-id=\"0eb6044\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"262\" height=\"300\" src=\"https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2022\/05\/favico-262x300.png\" class=\"attachment-medium size-medium wp-image-13\" alt=\"\" srcset=\"https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2022\/05\/favico-262x300.png 262w, https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2022\/05\/favico-895x1024.png 895w, https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2022\/05\/favico-768x878.png 768w, https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2022\/05\/favico.png 960w\" sizes=\"(max-width: 262px) 100vw, 262px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0f7959a elementor-widget elementor-widget-heading\" data-id=\"0f7959a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Brittney Williams<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-34b4d46 elementor-widget elementor-widget-text-editor\" data-id=\"34b4d46\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Clinical Trial Coordinator at Stanford University<\/p><p><span style=\"font-weight: 400;\">Ms. Williams is a clinical trials coordinator who worked with our team over the past 2 years. Ms. Williams will ensure regulatory compliance of all aspects of this study, obtain and maintain records of patient consents, and assist in managing overall study logistics.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-bf68b90\" data-id=\"bf68b90\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-c32122b\" data-id=\"c32122b\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-9a82b2b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"9a82b2b\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-95dee06\" data-id=\"95dee06\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-52f1cbc elementor-widget elementor-widget-heading\" data-id=\"52f1cbc\" data-element_type=\"widget\" data-e-type=\"widget\" id=\"facilities\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-large\">Facilities<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7177b36 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"7177b36\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-1189f73\" data-id=\"1189f73\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-52b16c1 elementor-widget elementor-widget-image\" data-id=\"52b16c1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1240\" height=\"799\" src=\"https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2022\/05\/Screen-Shot-2022-05-14-at-4.06.54-PM-e1654206678902.png\" class=\"attachment-full size-full wp-image-94\" alt=\"image of facility\" srcset=\"https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2022\/05\/Screen-Shot-2022-05-14-at-4.06.54-PM-e1654206678902.png 1240w, https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2022\/05\/Screen-Shot-2022-05-14-at-4.06.54-PM-e1654206678902-300x193.png 300w, https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2022\/05\/Screen-Shot-2022-05-14-at-4.06.54-PM-e1654206678902-1024x660.png 1024w, https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2022\/05\/Screen-Shot-2022-05-14-at-4.06.54-PM-e1654206678902-768x495.png 768w\" sizes=\"(max-width: 1240px) 100vw, 1240px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-8779439\" data-id=\"8779439\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c232884 elementor-widget elementor-widget-image\" data-id=\"c232884\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"931\" height=\"522\" src=\"https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2022\/06\/Screen-Shot-2022-06-02-at-5.45.44-PM.png\" class=\"attachment-full size-full wp-image-141\" alt=\"decorative\" srcset=\"https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2022\/06\/Screen-Shot-2022-06-02-at-5.45.44-PM.png 931w, https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2022\/06\/Screen-Shot-2022-06-02-at-5.45.44-PM-300x168.png 300w, https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2022\/06\/Screen-Shot-2022-06-02-at-5.45.44-PM-768x431.png 768w, https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2022\/06\/Screen-Shot-2022-06-02-at-5.45.44-PM-800x450.png 800w\" sizes=\"(max-width: 931px) 100vw, 931px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-2ab2be7 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2ab2be7\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-648789a\" data-id=\"648789a\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a27093d elementor-widget elementor-widget-text-editor\" data-id=\"a27093d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">The <\/span><span style=\"text-decoration: underline;\"><i><span style=\"font-weight: 400;\">Stanford Cancer Institute<\/span><\/i><\/span><span style=\"font-weight: 400;\"> focuses the world-class expertise of more than 240 researchers and clinicians on the most critical issues in cancer research and medicine today. These dedicated individuals work together in multidisciplinary teams to unravel cancer\u2019s secrets and to transform the latest detection, diagnosis, treatment and prevention discoveries into the most advanced patient care available. Combining these advances with comprehensive support services, the Stanford Cancer Institute is committed to giving patients every clinical and technological advantage in the prevention and treatment of cancer. <\/span><b>The infrastructure and resources of the Stanford Cancer Institute are available free of charge to cancer researchers<\/b><span style=\"font-weight: 400;\">.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-9507d2a\" data-id=\"9507d2a\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1c18705 elementor-widget elementor-widget-text-editor\" data-id=\"1c18705\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">The <\/span><span style=\"text-decoration: underline;\"><i><span style=\"font-weight: 400;\">Lorry I. Lokey Research Building<\/span><\/i><\/span><span style=\"font-weight: 400;\"> is located on the main campus within the School of Medicine, between the Lucas Center and the Stanford hospital. The Lokey Building is a 200,000-square-foot facility with 550 researchers in 33 different labs, which <\/span><b>includes the preclinical facilities of the Stanford Cancer Center<\/b><span style=\"font-weight: 400;\">. The institute integrates researchers from multiple specialties including cancer biology, stem cell biology, immunology and bioengineering. The building also has 60 hotel benches, where visiting scientists can come and do research as well.\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-f451433 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"f451433\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-2d929c8\" data-id=\"2d929c8\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-af51776 elementor-widget elementor-widget-text-editor\" data-id=\"af51776\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">The <\/span><span style=\"text-decoration: underline;\"><i><span style=\"font-weight: 400;\">Richard M. Lucas Center for Imaging<\/span><\/i><\/span> <span style=\"font-weight: 400;\">was established in 1992 and is the primary, centralized resource dedicated to biomedical imaging research on the Stanford University campus. With its current 37,000 nasf of space dedicated to molecular imaging, nanotechnology, MRI, PET, PET\/MR, and spectroscopy research, <\/span><b>the Lucas Center is one of the few centers in the world with major centralized resources devoted to research in the radiological sciences where both basic and clinical scientists are housed<\/b><span style=\"font-weight: 400;\">. The Lucas Center builds on a long-standing and very close working relationship between faculty and students of the Department of Radiology, the Stanford Cancer Institute as well as the Departments of Electrical Engineering, Bioengineering and Chemistry. The Center provides office and laboratory facilities for over 15 full-time faculty and their complement of more than 75 postdoctoral fellows and students. Dr. Moseley\u2019s office is located in the Lucas Center and our team has eight assigned desks for trainees in the Lucas Center. Major imaging devices available for research studies include one 3T Signa PET\/MRI scanner (GE Healthcare) as well as two 3.0T and one 7.0T MR scanner(s). Approximately one half of the Stanford Radiology 3D Imaging Laboratory (image data post-processing) is also located in the Lucas Center. With these resources, the Lucas Center is well suited for the preclinical development and clinical translation of novel imaging technologies. The Lucas Center is being used for preclinical imaging studies and clinical PET\/MR scans of patients for our project. The Lucas Center is located in approximately 5 minute walking distance to the Children\u2019s hospital. We conducted clinical trials at the Lucas Center for the last eight years and have established workflows to accompany pediatric patients from the Children\u2019s hospital to the Lucas Center.\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-2672a70\" data-id=\"2672a70\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9822606 elementor-widget elementor-widget-text-editor\" data-id=\"9822606\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">The <\/span><span style=\"text-decoration: underline;\"><i><span style=\"font-weight: 400;\">James H. Clark Center<\/span><\/i><\/span><span style=\"font-weight: 400;\"> fosters an unprecedented degree of collaboration between scientists from different disciplines in order to meet some of the most pressing scientific challenges of the coming decades. Such challenges can no longer be met by individuals working in isolation, but require the combined expertise of multi-disciplinary teams. The Clark Center lies at the heart of the Stanford campus between the core campus science engineering buildings and the hospital and medical facilities. Located on primary routes between the campus and the medical center, the building acts as a social magnet encouraging chance encounters and informal meetings between lecturers, researchers and students from diverse academic backgrounds. This provides a unique opportunity for our imaging researchers to interact and collaborate with basic scientists of different disciplines.<\/span> <span style=\"font-weight: 400;\">The lab interiors are a dramatic departure from tradition. The building has been turned inside out, with &#8216;corridors&#8217; replaced by external balconies, enabling completely flexible lab layouts. The three-story building takes the form of three wings of laboratories centered on an open courtyard overlooked by balconies. The Clark Center is home to approximately one half of the Radiology 3D Imaging Laboratory, the Molecular Imaging Lab, and the small animal imaging. <\/span><b>The Clark Center houses the small animal imaging laboratory, which is being used for preclinical imaging studies for this project.<\/b><span style=\"font-weight: 400;\"> The small animal imaging lab comprises a full complement of state-of-the-art small animal imaging equipmentas well as animals\u2019 surgery suites with a variety of surgical devices and micro- and macrotome facilities.\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7af55ca elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"7af55ca\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-aa868c0\" data-id=\"aa868c0\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-96da2bf elementor-widget elementor-widget-text-editor\" data-id=\"96da2bf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/med.stanford.edu\/sci3\" target=\"_blank\" rel=\"noopener\"><i><span style=\"font-weight: 400;\">Stanford Center for Innovation in In Vivo Imaging (SCi3)<\/span><\/i><\/a> <span style=\"font-weight: 400;\">is a state-of-the-art shared preclinical and translational imaging center to enable the understanding of the biology of health and disease, and to facilitate translation from <\/span><i><span style=\"font-weight: 400;\">in vitro<\/span><\/i><span style=\"font-weight: 400;\"> findings to <\/span><i><span style=\"font-weight: 400;\">in vivo<\/span><\/i><span style=\"font-weight: 400;\"> applications and clinical practice. Towards these goals, we continue to bring in the most cutting-edge imaging technologies available, including Bruker MRI system (3T, 7T\/PET and 11.7T),\u00a0 MicroPET\/CT, High resolution MicroCT, Optical imaging, Magnetic Particle Imager and Visual Sonic Ultrasound and photoacoustic systems. The facility also provides other equipment and animal surgery\/prep suites that facilitate multi-modality imaging. <\/span><b>The Clark Center houses the main small animal imaging laboratory, which is being used for preclinical imaging studies for this project.<\/b><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-656bdad\" data-id=\"656bdad\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a72ca03 elementor-widget elementor-widget-text-editor\" data-id=\"a72ca03\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"text-decoration: underline;\"><i><span style=\"font-weight: 400;\">Stanford Nanocharacterization lab:<\/span><\/i><\/span><span style=\"font-weight: 400;\"> Stanford offers several shared facilities for nanoparticle research, including the\u00a0Stanford Nano Center (SNC) and the Stanford Nanofabrication Facility (SNF), which are part of Stanford&#8217;s National Nanotechnology Infrastructure Network (NNIN)\u00a0program. These core facilities provide access to a wide array of shared instruments, such as mass spectrometers, high-resolution microscopes, X-ray diffractometers and surface science analytical instruments (among many others) that are available for all qualified users in the Stanford community, and for Stanford collaborators both locally and globally. The NNIN program provides an infrastructure for nanoparticle synthesis, generation of high-quality data on nanomaterials and related data analyses and interpretation. <\/span><b>This provides a unique resource for our planned nanoparticle biodistribution studies.<\/b><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1414ee4 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1414ee4\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-89d06d6\" data-id=\"89d06d6\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-895810a elementor-widget elementor-widget-text-editor\" data-id=\"895810a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">The <\/span><span style=\"text-decoration: underline;\"><i><span style=\"font-weight: 400;\">Daldrup-Link Lab<\/span><\/i><\/span><span style=\"font-weight: 400;\"> is located in the Lokey building and comprises benches and desks for research fellows as well as a fully equipped cell culture lab with three cell culture hoods, two incubators (one low oxygen incubator), one refrigerator, one freezer, two centrifuges, one microscope, an autoclave, and a variety of additional small equipment (see details below). All personnel involved in this research have access to Dr. Daldrup-Link\u2019s laboratory. Preclinical studies for this project are being performed in the Daldrup-Link lab.\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-646c65d\" data-id=\"646c65d\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-092e9cf elementor-widget elementor-widget-text-editor\" data-id=\"092e9cf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"text-decoration: underline;\"><em>Lucile Salter Packard Children&#8217;s Hospital (LPCH)<\/em><\/span><i><\/i><b><i>,<\/i><\/b><span style=\"font-weight: 400;\"> ranked as one of the nation&#8217;s top pediatric hospitals, is a 361-bed hospital for children and expectant mothers, located next to the Stanford Hospital on the University campus. With over 750 physicians and 5000 staff support and volunteers, Packard Children&#8217;s Hospital is a world-class, non-profit hospital devoted entirely to medical and surgical care of babies, children, adolescents and expectant mothers, offering the full range of health care of pediatric and obstetric services, from preventive and routine care to specialized services. Supported by the academic resources at the Stanford University School of Medicine, Packard Children\u2019s brings world-class medicine right to the bedside.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4e9530f elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4e9530f\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-7576951\" data-id=\"7576951\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d310d88 elementor-widget elementor-widget-text-editor\" data-id=\"d310d88\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">The <\/span><span style=\"text-decoration: underline;\"><i>Division of Pediatric Hematology and Oncology at LPCH<\/i><\/span> is one of the largest and most active in the country<span style=\"font-weight: 400;\"> with 20 full time faculty members. All members of the division are actively involved in research. The division has more than 50 active research projects with peer-reviewed funding. Senior faculty members play key roles in the Children\u2019s Oncology Group and in other national and international research consortium.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-9e3a0be\" data-id=\"9e3a0be\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-113750c elementor-widget elementor-widget-image\" data-id=\"113750c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"271\" height=\"300\" src=\"https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2022\/05\/Screen-Shot-2022-05-14-at-4.07.01-PM-271x300.png\" class=\"attachment-medium size-medium wp-image-95\" alt=\"decorative image\" srcset=\"https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2022\/05\/Screen-Shot-2022-05-14-at-4.07.01-PM-271x300.png 271w, https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2022\/05\/Screen-Shot-2022-05-14-at-4.07.01-PM.png 632w\" sizes=\"(max-width: 271px) 100vw, 271px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-919ced3 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"919ced3\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-88116f4\" data-id=\"88116f4\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-73ccc52 elementor-widget elementor-widget-text-editor\" data-id=\"73ccc52\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>References\u00a0<\/b><\/p><ol><li><span style=\"font-weight: 400;\">Bernthal NM, Federman N, Eilber FR, et al. Long-term results (&gt;25 years) of a randomized, prospective clinical trial evaluating chemotherapy in patients with high-grade, operable osteosarcoma. <\/span><i><span style=\"font-weight: 400;\">Cancer<\/span><\/i><span style=\"font-weight: 400;\"> 2012; <\/span><b>118<\/b><span style=\"font-weight: 400;\">(23): 5888-93.<\/span><\/li><li><span style=\"font-weight: 400;\">Rodriguez-Galindo C, Navid F, Liu T, Billups CA, Rao BN, Krasin MJ. Prognostic factors for local and distant control in Ewing sarcoma family of tumors. <\/span><i><span style=\"font-weight: 400;\">Annals of oncology : official journal of the European Society for Medical Oncology \/ ESMO<\/span><\/i><span style=\"font-weight: 400;\"> 2008; <\/span><b>19<\/b><span style=\"font-weight: 400;\">(4): 814-20.<\/span><\/li><li><span style=\"font-weight: 400;\">Zhu L, McManus MM, Hughes DP. Understanding the Biology of Bone Sarcoma from Early Initiating Events through Late Events in Metastasis and Disease Progression. <\/span><i><span style=\"font-weight: 400;\">Frontiers in oncology<\/span><\/i><span style=\"font-weight: 400;\"> 2013; <\/span><b>3<\/b><span style=\"font-weight: 400;\">: 230.<\/span><\/li><li><span style=\"font-weight: 400;\">Bernstein ML, Devidas M, Lafreniere D, et al. Intensive therapy with growth factor support for patients with Ewing tumor metastatic at diagnosis: Pediatric Oncology Group\/Children&#8217;s Cancer Group Phase II Study 9457&#8211;a report from the Children&#8217;s Oncology Group. <\/span><i><span style=\"font-weight: 400;\">J Clin Oncol<\/span><\/i><span style=\"font-weight: 400;\"> 2006; <\/span><b>24<\/b><span style=\"font-weight: 400;\">(1): 152-9.<\/span><\/li><li><span style=\"font-weight: 400;\">Cangir A, Vietti TJ, Gehan EA, et al. Ewing&#8217;s sarcoma metastatic at diagnosis. Results and comparisons of two intergroup Ewing&#8217;s sarcoma studies. <\/span><i><span style=\"font-weight: 400;\">Cancer<\/span><\/i><span style=\"font-weight: 400;\"> 1990; <\/span><b>66<\/b><span style=\"font-weight: 400;\">(5): 887-93.<\/span><\/li><li><span style=\"font-weight: 400;\">Ladenstein R, Potschger U, Le Deley MC, et al. Primary disseminated multifocal Ewing sarcoma: results of the Euro-EWING 99 trial. <\/span><i><span style=\"font-weight: 400;\">J Clin Oncol<\/span><\/i><span style=\"font-weight: 400;\"> 2010; <\/span><b>28<\/b><span style=\"font-weight: 400;\">(20): 3284-91.<\/span><\/li><li><span style=\"font-weight: 400;\">Miser JS, Krailo MD, Tarbell NJ, et al. Treatment of metastatic Ewing&#8217;s sarcoma or primitive neuroectodermal tumor of bone: evaluation of combination ifosfamide and etoposide&#8211;a Children&#8217;s Cancer Group and Pediatric Oncology Group study. <\/span><i><span style=\"font-weight: 400;\">J Clin Oncol<\/span><\/i><span style=\"font-weight: 400;\"> 2004; <\/span><b>22<\/b><span style=\"font-weight: 400;\">(14): 2873-6.<\/span><\/li><li><span style=\"font-weight: 400;\">Paulussen M, Ahrens S, Burdach S, et al. Primary metastatic (stage IV) Ewing tumor: survival analysis of 171 patients from the EICESS studies. European Intergroup Cooperative Ewing Sarcoma Studies. <\/span><i><span style=\"font-weight: 400;\">Ann Oncol<\/span><\/i><span style=\"font-weight: 400;\"> 1998; <\/span><b>9<\/b><span style=\"font-weight: 400;\">(3): 275-81.<\/span><\/li><li><span style=\"font-weight: 400;\">Bakhshi S, Radhakrishnan V. Prognostic markers in osteosarcoma. <\/span><i><span style=\"font-weight: 400;\">Expert Rev Anticancer Ther<\/span><\/i><span style=\"font-weight: 400;\"> 2010; <\/span><b>10<\/b><span style=\"font-weight: 400;\">(2): 271-87.<\/span><\/li><li><span style=\"font-weight: 400;\">Mialou V, Philip T, Kalifa C, et al. Metastatic osteosarcoma at diagnosis: prognostic factors and long-term outcome&#8211;the French pediatric experience. <\/span><i><span style=\"font-weight: 400;\">Cancer<\/span><\/i><span style=\"font-weight: 400;\"> 2005; <\/span><b>104<\/b><span style=\"font-weight: 400;\">(5): 1100-9.<\/span><\/li><li><span style=\"font-weight: 400;\">Xu JF, Pan XH, Zhang SJ, et al. CD47 blockade inhibits tumor progression human osteosarcoma in xenograft models. <\/span><i><span style=\"font-weight: 400;\">Oncotarget<\/span><\/i><span style=\"font-weight: 400;\"> 2015; <\/span><b>6<\/b><span style=\"font-weight: 400;\">(27): 23662-70.<\/span><\/li><li><span style=\"font-weight: 400;\">Zhao XW, van Beek EM, Schornagel K, et al. CD47-signal regulatory protein-alpha (SIRPalpha) interactions form a barrier for antibody-mediated tumor cell destruction. <\/span><i><span style=\"font-weight: 400;\">Proc Natl Acad Sci U S A<\/span><\/i><span style=\"font-weight: 400;\"> 2011; <\/span><b>108<\/b><span style=\"font-weight: 400;\">(45): 18342-7.<\/span><\/li><li><span style=\"font-weight: 400;\">Chao MP, Weissman IL, Majeti R. The CD47-SIRPalpha pathway in cancer immune evasion and potential therapeutic implications. <\/span><i><span style=\"font-weight: 400;\">Curr Opin Immunol<\/span><\/i><span style=\"font-weight: 400;\"> 2012; <\/span><b>24<\/b><span style=\"font-weight: 400;\">(2): 225-32.<\/span><\/li><li><span style=\"font-weight: 400;\">Majeti R, Chao MP, Alizadeh AA, et al. CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells. <\/span><i><span style=\"font-weight: 400;\">Cell<\/span><\/i><span style=\"font-weight: 400;\"> 2009; <\/span><b>138<\/b><span style=\"font-weight: 400;\">(2): 286-99.<\/span><\/li><li><span style=\"font-weight: 400;\">Chao MP, Alizadeh AA, Tang C, et al. Anti-CD47 antibody synergizes with rituximab to promote phagocytosis and eradicate non-Hodgkin lymphoma. <\/span><i><span style=\"font-weight: 400;\">Cell<\/span><\/i><span style=\"font-weight: 400;\"> 2010; <\/span><b>142<\/b><span style=\"font-weight: 400;\">(5): 699-713.<\/span><\/li><li><span style=\"font-weight: 400;\">Edris B, Weiskopf K, Volkmer AK, et al. Antibody therapy targeting the CD47 protein is effective in a model of aggressive metastatic leiomyosarcoma. <\/span><i><span style=\"font-weight: 400;\">Proc Natl Acad Sci U S A<\/span><\/i><span style=\"font-weight: 400;\"> 2012; <\/span><b>109<\/b><span style=\"font-weight: 400;\">(17): 6656-61.<\/span><\/li><li><span style=\"font-weight: 400;\">Chao MP, Jaiswal S, Weissman-Tsukamoto R, et al. Calreticulin is the dominant pro-phagocytic signal on multiple human cancers and is counterbalanced by CD47. <\/span><i><span style=\"font-weight: 400;\">Sci Transl Med<\/span><\/i><span style=\"font-weight: 400;\"> 2010; <\/span><b>2<\/b><span style=\"font-weight: 400;\">(63): 63ra94.<\/span><\/li><li><span style=\"font-weight: 400;\">Chao MP, Alizadeh AA, Tang C, et al. Therapeutic antibody targeting of CD47 eliminates human acute lymphoblastic leukemia. <\/span><i><span style=\"font-weight: 400;\">Cancer Res<\/span><\/i><span style=\"font-weight: 400;\"> 2011; <\/span><b>71<\/b><span style=\"font-weight: 400;\">(4): 1374-84.<\/span><\/li><li><span style=\"font-weight: 400;\">Edris B, Weiskopf K, Volkmer AK, et al. Antibody therapy targeting the CD47 protein is effective in a model of aggressive metastatic leiomyosarcoma. <\/span><i><span style=\"font-weight: 400;\">Proceedings of the National Academy of Sciences<\/span><\/i><span style=\"font-weight: 400;\"> 2012; <\/span><b>109<\/b><span style=\"font-weight: 400;\">(17): 6656-61.<\/span><\/li><li><span style=\"font-weight: 400;\">Herrmann D, Seitz G, Fuchs J, Armeanu-Ebinger S. Susceptibility of rhabdomyosarcoma cells to macrophage-mediated cytotoxicity. <\/span><i><span style=\"font-weight: 400;\">Oncoimmunology<\/span><\/i><span style=\"font-weight: 400;\"> 2012; <\/span><b>1<\/b><span style=\"font-weight: 400;\">(3): 279-86.<\/span><\/li><li><span style=\"font-weight: 400;\">Mohanty S, Yerneni K, Theruvath JL, et al. Nanoparticle enhanced MRI can monitor macrophage response to CD47 mAb immunotherapy in osteosarcoma. <\/span><i><span style=\"font-weight: 400;\">Cell Death and Disease<\/span><\/i><span style=\"font-weight: 400;\"> 2019; <\/span><b>10<\/b><span style=\"font-weight: 400;\">: 1-14.<\/span><\/li><li><span style=\"font-weight: 400;\">Aghighi M, Theruvath AJ, Pareek A, et al. Magnetic Resonance Imaging of Tumor Associated Macrophages: Clinical Translation. <\/span><i><span style=\"font-weight: 400;\">Clin Cancer Res<\/span><\/i><span style=\"font-weight: 400;\"> 2018.<\/span><\/li><li><span style=\"font-weight: 400;\">Daldrup-Link HE, Golovko D, Ruffell B, et al. MRI of tumor-associated macrophages with clinically applicable iron oxide nanoparticles. <\/span><i><span style=\"font-weight: 400;\">Clinical Cancer Research<\/span><\/i><span style=\"font-weight: 400;\"> 2011; <\/span><b>17<\/b><span style=\"font-weight: 400;\">(17): 5695-704.<\/span><\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-92ddb63 elementor-widget elementor-widget-spacer\" data-id=\"92ddb63\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>About Stanford CIRP Project Aims Aim 1 Aim 2 Aim 3 Long-term Impact Project Aims Advances in diagnosis, surgery and chemotherapy have improved clinical outcomes for patients with localized bone sarcomas1-3. However, the overall survival of patients with metastatic disease continues to be less than 30%4-10. Thus, there is an urgent need for new therapies [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_monsterinsights_skip_tracking":false,"ocean_front_end_style_editor":"no","ocean_post_layout":"","ocean_both_sidebars_style":"","ocean_both_sidebars_content_width":0,"ocean_both_sidebars_sidebars_width":0,"ocean_sidebar":"0","ocean_second_sidebar":"0","ocean_disable_margins":"enable","ocean_add_body_class":"","ocean_shortcode_before_top_bar":"","ocean_shortcode_after_top_bar":"","ocean_shortcode_before_header":"","ocean_shortcode_after_header":"","ocean_has_shortcode":"","ocean_shortcode_after_title":"","ocean_shortcode_before_footer_widgets":"","ocean_shortcode_after_footer_widgets":"","ocean_shortcode_before_footer_bottom":"","ocean_shortcode_after_footer_bottom":"","ocean_display_top_bar":"default","ocean_display_header":"default","ocean_header_style":"","ocean_center_header_left_menu":"0","ocean_custom_header_template":"0","ocean_custom_logo":0,"ocean_custom_retina_logo":0,"ocean_custom_logo_max_width":0,"ocean_custom_logo_tablet_max_width":0,"ocean_custom_logo_mobile_max_width":0,"ocean_custom_logo_max_height":0,"ocean_custom_logo_tablet_max_height":0,"ocean_custom_logo_mobile_max_height":0,"ocean_header_custom_menu":"0","ocean_menu_typo_font_family":"0","ocean_menu_typo_font_subset":"","ocean_menu_typo_font_size":0,"ocean_menu_typo_font_size_tablet":0,"ocean_menu_typo_font_size_mobile":0,"ocean_menu_typo_font_size_unit":"px","ocean_menu_typo_font_weight":"","ocean_menu_typo_font_weight_tablet":"","ocean_menu_typo_font_weight_mobile":"","ocean_menu_typo_transform":"","ocean_menu_typo_transform_tablet":"","ocean_menu_typo_transform_mobile":"","ocean_menu_typo_line_height":0,"ocean_menu_typo_line_height_tablet":0,"ocean_menu_typo_line_height_mobile":0,"ocean_menu_typo_line_height_unit":"","ocean_menu_typo_spacing":0,"ocean_menu_typo_spacing_tablet":0,"ocean_menu_typo_spacing_mobile":0,"ocean_menu_typo_spacing_unit":"","ocean_menu_link_color":"","ocean_menu_link_color_hover":"","ocean_menu_link_color_active":"","ocean_menu_link_background":"","ocean_menu_link_hover_background":"","ocean_menu_link_active_background":"","ocean_menu_social_links_bg":"","ocean_menu_social_hover_links_bg":"","ocean_menu_social_links_color":"","ocean_menu_social_hover_links_color":"","ocean_disable_title":"on","ocean_disable_heading":"default","ocean_post_title":"","ocean_post_subheading":"","ocean_post_title_style":"","ocean_post_title_background_color":"","ocean_post_title_background":0,"ocean_post_title_bg_image_position":"","ocean_post_title_bg_image_attachment":"","ocean_post_title_bg_image_repeat":"","ocean_post_title_bg_image_size":"","ocean_post_title_height":0,"ocean_post_title_bg_overlay":0.5,"ocean_post_title_bg_overlay_color":"","ocean_disable_breadcrumbs":"default","ocean_breadcrumbs_color":"","ocean_breadcrumbs_separator_color":"","ocean_breadcrumbs_links_color":"","ocean_breadcrumbs_links_hover_color":"","ocean_display_footer_widgets":"default","ocean_display_footer_bottom":"default","ocean_custom_footer_template":"0","footnotes":""},"class_list":["post-11","page","type-page","status-publish","hentry","entry"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 5.0.3 - aioseo.com -->\n\t<meta name=\"description\" content=\"Learn about the Stanford CIRP Project Aims, The Project Team and Our Facilities\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<link rel=\"canonical\" href=\"https:\/\/radweb.su.domains\/cirp\/about\/\" \/>\n\t\t<meta name=\"generator\" content=\"All in One SEO (AIOSEO) 5.0.3\" \/>\n\t\t<meta property=\"og:locale\" content=\"en_US\" \/>\n\t\t<meta property=\"og:site_name\" content=\"Co-Clinical Research for Imaging Tumor Associated Macrophages - U24CA264298\" \/>\n\t\t<meta property=\"og:type\" content=\"article\" \/>\n\t\t<meta property=\"og:title\" content=\"About Stanford CIRP Co-Clinical Research for Imaging Tumor Associated Macrophages\" \/>\n\t\t<meta property=\"og:description\" content=\"Learn about the Stanford CIRP Project Aims, The Project Team and Our Facilities\" \/>\n\t\t<meta property=\"og:url\" content=\"https:\/\/radweb.su.domains\/cirp\/about\/\" \/>\n\t\t<meta property=\"og:image\" content=\"https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2022\/05\/web-logo-color-filled-shield.png\" \/>\n\t\t<meta property=\"og:image:secure_url\" content=\"https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2022\/05\/web-logo-color-filled-shield.png\" \/>\n\t\t<meta property=\"article:published_time\" content=\"2022-05-11T17:41:07+00:00\" \/>\n\t\t<meta property=\"article:modified_time\" content=\"2023-04-20T16:36:29+00:00\" \/>\n\t\t<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n\t\t<meta name=\"twitter:title\" content=\"About Stanford CIRP Co-Clinical Research for Imaging Tumor Associated Macrophages\" \/>\n\t\t<meta name=\"twitter:description\" content=\"Learn about the Stanford CIRP Project Aims, The Project Team and Our Facilities\" \/>\n\t\t<meta name=\"twitter:image\" content=\"https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2022\/05\/web-logo-color-filled-shield.png\" \/>\n\t\t<script type=\"application\/ld+json\" class=\"aioseo-schema\">\n\t\t\t{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/radweb.su.domains\\\/cirp\\\/about\\\/#breadcrumblist\",\"itemListElement\":[{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/radweb.su.domains\\\/cirp\\\/#listItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/radweb.su.domains\\\/cirp\\\/\",\"nextItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/radweb.su.domains\\\/cirp\\\/about\\\/#listItem\",\"name\":\"About\"}},{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/radweb.su.domains\\\/cirp\\\/about\\\/#listItem\",\"position\":2,\"name\":\"About\",\"previousItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/radweb.su.domains\\\/cirp\\\/#listItem\",\"name\":\"Home\"}}]},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/radweb.su.domains\\\/cirp\\\/#organization\",\"name\":\"Co-Clinical Research for Imaging Tumor Associated Macrophages | Stanford\",\"description\":\"U24CA264298\",\"url\":\"https:\\\/\\\/radweb.su.domains\\\/cirp\\\/\",\"telephone\":\"+16507231127\",\"logo\":{\"@type\":\"ImageObject\",\"url\":\"https:\\\/\\\/radweb.su.domains\\\/cirp\\\/wp-content\\\/uploads\\\/2022\\\/05\\\/web-logo-color-filled-shield.png\",\"@id\":\"https:\\\/\\\/radweb.su.domains\\\/cirp\\\/about\\\/#organizationLogo\",\"width\":1217,\"height\":212,\"caption\":\"Stanford Medicine | Radiology\"},\"image\":{\"@id\":\"https:\\\/\\\/radweb.su.domains\\\/cirp\\\/about\\\/#organizationLogo\"}},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/radweb.su.domains\\\/cirp\\\/about\\\/#webpage\",\"url\":\"https:\\\/\\\/radweb.su.domains\\\/cirp\\\/about\\\/\",\"name\":\"About Stanford CIRP Co-Clinical Research for Imaging Tumor Associated Macrophages\",\"description\":\"Learn about the Stanford CIRP Project Aims, The Project Team and Our Facilities\",\"inLanguage\":\"en\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/radweb.su.domains\\\/cirp\\\/#website\"},\"breadcrumb\":{\"@id\":\"https:\\\/\\\/radweb.su.domains\\\/cirp\\\/about\\\/#breadcrumblist\"},\"datePublished\":\"2022-05-11T17:41:07+00:00\",\"dateModified\":\"2023-04-20T16:36:29+00:00\"},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/radweb.su.domains\\\/cirp\\\/#website\",\"url\":\"https:\\\/\\\/radweb.su.domains\\\/cirp\\\/\",\"name\":\"Co-Clinical Research for Imaging Tumor Associated Macrophages\",\"description\":\"U24CA264298\",\"inLanguage\":\"en\",\"publisher\":{\"@id\":\"https:\\\/\\\/radweb.su.domains\\\/cirp\\\/#organization\"}}]}\n\t\t<\/script>\n\t\t<!-- All in One SEO -->\n\n","aioseo_head_json":{"title":"About Stanford CIRP Co-Clinical Research for Imaging Tumor Associated Macrophages","description":"Learn about the Stanford CIRP Project Aims, The Project Team and Our Facilities","canonical_url":"https:\/\/radweb.su.domains\/cirp\/about\/","robots":"max-image-preview:large","keywords":"","webmasterTools":{"miscellaneous":""},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"BreadcrumbList","@id":"https:\/\/radweb.su.domains\/cirp\/about\/#breadcrumblist","itemListElement":[{"@type":"ListItem","@id":"https:\/\/radweb.su.domains\/cirp\/#listItem","position":1,"name":"Home","item":"https:\/\/radweb.su.domains\/cirp\/","nextItem":{"@type":"ListItem","@id":"https:\/\/radweb.su.domains\/cirp\/about\/#listItem","name":"About"}},{"@type":"ListItem","@id":"https:\/\/radweb.su.domains\/cirp\/about\/#listItem","position":2,"name":"About","previousItem":{"@type":"ListItem","@id":"https:\/\/radweb.su.domains\/cirp\/#listItem","name":"Home"}}]},{"@type":"Organization","@id":"https:\/\/radweb.su.domains\/cirp\/#organization","name":"Co-Clinical Research for Imaging Tumor Associated Macrophages | Stanford","description":"U24CA264298","url":"https:\/\/radweb.su.domains\/cirp\/","telephone":"+16507231127","logo":{"@type":"ImageObject","url":"https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2022\/05\/web-logo-color-filled-shield.png","@id":"https:\/\/radweb.su.domains\/cirp\/about\/#organizationLogo","width":1217,"height":212,"caption":"Stanford Medicine | Radiology"},"image":{"@id":"https:\/\/radweb.su.domains\/cirp\/about\/#organizationLogo"}},{"@type":"WebPage","@id":"https:\/\/radweb.su.domains\/cirp\/about\/#webpage","url":"https:\/\/radweb.su.domains\/cirp\/about\/","name":"About Stanford CIRP Co-Clinical Research for Imaging Tumor Associated Macrophages","description":"Learn about the Stanford CIRP Project Aims, The Project Team and Our Facilities","inLanguage":"en","isPartOf":{"@id":"https:\/\/radweb.su.domains\/cirp\/#website"},"breadcrumb":{"@id":"https:\/\/radweb.su.domains\/cirp\/about\/#breadcrumblist"},"datePublished":"2022-05-11T17:41:07+00:00","dateModified":"2023-04-20T16:36:29+00:00"},{"@type":"WebSite","@id":"https:\/\/radweb.su.domains\/cirp\/#website","url":"https:\/\/radweb.su.domains\/cirp\/","name":"Co-Clinical Research for Imaging Tumor Associated Macrophages","description":"U24CA264298","inLanguage":"en","publisher":{"@id":"https:\/\/radweb.su.domains\/cirp\/#organization"}}]},"og:locale":"en_US","og:site_name":"Co-Clinical Research for Imaging Tumor Associated Macrophages - U24CA264298","og:type":"article","og:title":"About Stanford CIRP Co-Clinical Research for Imaging Tumor Associated Macrophages","og:description":"Learn about the Stanford CIRP Project Aims, The Project Team and Our Facilities","og:url":"https:\/\/radweb.su.domains\/cirp\/about\/","og:image":"https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2022\/05\/web-logo-color-filled-shield.png","og:image:secure_url":"https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2022\/05\/web-logo-color-filled-shield.png","article:published_time":"2022-05-11T17:41:07+00:00","article:modified_time":"2023-04-20T16:36:29+00:00","twitter:card":"summary_large_image","twitter:title":"About Stanford CIRP Co-Clinical Research for Imaging Tumor Associated Macrophages","twitter:description":"Learn about the Stanford CIRP Project Aims, The Project Team and Our Facilities","twitter:image":"https:\/\/radweb.su.domains\/cirp\/wp-content\/uploads\/2022\/05\/web-logo-color-filled-shield.png"},"aioseo_meta_data":{"post_id":"11","title":"#post_title Stanford CIRP #site_title","description":"Learn about the Stanford CIRP Project Aims, The Project Team and Our Facilities","keywords":null,"keyphrases":null,"primary_term":null,"canonical_url":null,"og_title":null,"og_description":null,"og_object_type":"default","og_image_type":"default","og_image_url":null,"og_image_width":null,"og_image_height":null,"og_image_custom_url":null,"og_image_custom_fields":null,"og_video":null,"og_custom_url":null,"og_article_section":null,"og_article_tags":null,"twitter_use_og":false,"twitter_card":"default","twitter_image_type":"default","twitter_image_url":null,"twitter_image_custom_url":null,"twitter_image_custom_fields":null,"twitter_title":null,"twitter_description":null,"schema":{"blockGraphs":[],"customGraphs":[],"default":{"data":{"Article":[],"Course":[],"Dataset":[],"FAQPage":[],"Movie":[],"Person":[],"Product":[],"ProductReview":[],"Car":[],"Recipe":[],"Service":[],"SoftwareApplication":[],"WebPage":[]},"graphName":"","isEnabled":true},"graphs":[],"defaultGraph":"","defaultPostTypeGraph":""},"schema_type":"default","schema_type_options":null,"pillar_content":false,"robots_default":true,"robots_noindex":false,"robots_noarchive":false,"robots_nosnippet":false,"robots_nofollow":false,"robots_noimageindex":false,"robots_noodp":false,"robots_notranslate":false,"robots_max_snippet":null,"robots_max_videopreview":null,"robots_max_imagepreview":"large","priority":null,"frequency":null,"local_seo":null,"breadcrumb_settings":null,"limit_modified_date":false,"ai":null,"created":"2022-09-01 17:35:48","updated":"2025-06-04 15:28:19","seo_analyzer_scan_date":null,"focus_keyword":null,"additional_keywords":null,"truseo_locale":null},"aioseo_breadcrumb":"<div class=\"aioseo-breadcrumbs\"><span class=\"aioseo-breadcrumb\">\n\t\t\t<a href=\"https:\/\/radweb.su.domains\/cirp\/\" title=\"Home\">Home<\/a>\n\t\t<\/span><span class=\"aioseo-breadcrumb-separator\">\u00bb<\/span><span class=\"aioseo-breadcrumb\">\n\t\t\tAbout\n\t\t<\/span><\/div>","aioseo_breadcrumb_json":[{"label":"Home","link":"https:\/\/radweb.su.domains\/cirp\/"},{"label":"About","link":"https:\/\/radweb.su.domains\/cirp\/about\/"}],"_links":{"self":[{"href":"https:\/\/radweb.su.domains\/cirp\/wp-json\/wp\/v2\/pages\/11","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/radweb.su.domains\/cirp\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/radweb.su.domains\/cirp\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/radweb.su.domains\/cirp\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/radweb.su.domains\/cirp\/wp-json\/wp\/v2\/comments?post=11"}],"version-history":[{"count":46,"href":"https:\/\/radweb.su.domains\/cirp\/wp-json\/wp\/v2\/pages\/11\/revisions"}],"predecessor-version":[{"id":209,"href":"https:\/\/radweb.su.domains\/cirp\/wp-json\/wp\/v2\/pages\/11\/revisions\/209"}],"wp:attachment":[{"href":"https:\/\/radweb.su.domains\/cirp\/wp-json\/wp\/v2\/media?parent=11"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}